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KMID : 1145120220200040385
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Asian Journal of Beauty and Cosmetology
2022 Volume.20 No. 4 p.385 ~ p.392
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Efficacy of Acetyl Hexapeptide-8 Ampoule on Improvement of Elasticity in C3H Mice Skin
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Kim Min-Jung
An Eun-Joo
Jo Hae-Won
Kim Jeong-Hee
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Abstract
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Purpose : Acetyl hexapeptide-8 (AH-8) had been reportedly effective in improving keratinocytes. Ampoules containing AH-8 as an active ingredient were prepared, and their efficacy for improving skin elasticity was evaluated.
Methods : Ampoules containing 3% and 5% AH-8 were prepared, and their efficacy was evaluated. C3H mice were pretreated with different AH-8 ampoule concentrations and then irradiated with UVB for 6 weeks. Changes in the number of collagen and elastic fibers from paraffin-embedded skin tissues were quantitatively measured using an image analysis program.
Results : Our data showed that the skin of C3H mice with UVB-irradiated markedly decreased the collagen levels compared to the control. Moreover, pretreatment of 3% and 5% AH-8 ampoules on UVB irradiation increased collagen production. Furthermore, the elastin production was decreased in the UVB-irradiated group compared to the control and the elastin level in the skin of C3H mice was similar in both pretreated with 5% AH-8 on the UVB irradiation and control groups.
Conclusions : This study has proven that HA-8 ampoules had a high capability of improving elasticity when compared to vehicle ampoule-containing ginkgo leaf and green tea extracts. Moreover, this study revealed the efficacy of AH-8 for increasing skin elasticity in terms of a cosmetic active ingredient.
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KEYWORD
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Acetyl hexapeptide-8, UVB, Histological changes, Collagen, Elastic fiber
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